Fat loss peptides work through distinct mechanisms — from GLP-1 receptor agonism to direct lipolysis activation. Here's a breakdown of the best options available in India in 2026.
1. Retatrutide — Triple Agonist
Retatrutide targets three receptors simultaneously: GIP, GLP-1, and glucagon. This triple mechanism drives appetite suppression, improved insulin sensitivity, and direct fat oxidation. Phase 2 clinical trials showed 17–24% mean body weight reduction over 48 weeks — the highest of any peptide class.
Dosage: 2–12 mg/week | Half-life: ~6 days | Price: ₹4,999/10mg
2. Tirzepatide — Dual Agonist
Tirzepatide targets GIP and GLP-1 receptors. As the basis for Mounjaro, it has robust Phase 3 clinical data showing 15–20% weight reduction with improvements in HbA1c and metabolic markers.
Dosage: 2.5–15 mg/week | Half-life: ~5 days | Price: ₹5,999/20mg
3. AOD-9604 — Targeted Lipolysis
AOD-9604 is the C-terminus fragment of human growth hormone (amino acids 177-191). It activates fat-burning lipolysis pathways without the growth-promoting effects of full HGH. Particularly researched for visceral and subcutaneous fat reduction.
Dosage: 300 mcg/day | Half-life: ~30 minutes | Price: ₹3,799/5mg
4. MOTS-C — Metabolic Flexibility
MOTS-C is a mitochondria-derived peptide that activates AMPK and improves insulin sensitivity. Rather than directly burning fat, it enhances metabolic flexibility — the body's ability to switch between fuel sources. Researched in longevity contexts as well as fat loss.
Dosage: 5–10 mg 3×/week | Half-life: ~24 hours | Price: ₹2,999/10mg
Which Fat Loss Peptide Should You Choose?
For maximum fat loss: Retatrutide. For clinically-proven dual agonism: Tirzepatide. For targeted lipolysis at low cost: AOD-9604. For metabolic health and fat loss combined: MOTS-C.
Browse all fat loss peptides or compare Retatrutide vs Tirzepatide.