What is Semax?
Semax is a synthetic heptapeptide analogue of the N-terminal fragment of ACTH (adrenocorticotropic hormone), developed in Russia and approved for medical use in the Russian Federation for cognitive impairment and ischemic conditions. Its sequence (Met-Glu-His-Phe-Pro-Gly-Pro) upregulates Brain-Derived Neurotrophic Factor (BDNF), promotes myelination, and enhances dopaminergic and serotonergic neurotransmission — making it one of the most well-researched peptide nootropics available.
Research Benefits
- Upregulates BDNF (Brain-Derived Neurotrophic Factor) — critical for neuroplasticity and learning
- Enhances working memory, focus, and information processing speed
- Promotes myelination — the protective coating of nerve fibers essential for neural signal speed
- Studied for neuroprotection following ischemic injury and cognitive decline
- Modulates dopaminergic and serotonergic systems for improved mood and motivation
- Anti-anxiety effects via enkephalin system modulation without sedation
Dosage & Protocol
Research protocols use 300–600 mcg per day administered intranasally or subcutaneously. Intranasal delivery is preferred for direct CNS access via the olfactory epithelium. The ~8-hour half-life supports once or twice-daily dosing. Standard research cycles are 2–4 weeks with sensitivity reassessment periods.
Frequently Asked Questions
Semax is primarily studied via intranasal administration (nasal drops), which allows direct CNS penetration via the olfactory epithelium. Subcutaneous injection is also used. Intranasal delivery at 200–300 mcg per nostril is the most common research protocol.
Semax is researched for enhanced working memory, improved focus and attention, accelerated learning, and neuroplasticity via BDNF upregulation. It is also studied for neuroprotection in cognitive decline models and ischemic brain injury recovery.
Yes. Semax (stimulating/nootropic) and Selank (anxiolytic/calming) are commonly co-administered in research. Semax drives BDNF and cognitive enhancement while Selank modulates GABA and serotonin to reduce anxiety — producing a balanced focus-without-anxiety profile.